PET Whole Body Distribution Studies Using [11C]CUMI. Evaluation study. Background: - Researchers studying new treatments for major depressive disorder are looking at how medications to treat depression act on the brain chemical serotonin, which interacts with specific serotonin receptors on brain cells. Ages 18-65. Location in Bethesda, MD.
Integrated Treatment for Comorbid Depression and Obesity in Adolescents. Interventional study. Lifetime prevalence of major depression is estimated at 28% by age 18 (Lewinsohn et al., 1999), with higher cumulative rates in females (35%) than males (19%). Ages 12-18. Location in Providence, RI.
Biomarkers for Outcomes In Late-life Depression (BOLD). Interventional study. Major depressive disorder (MDD) is a common psychiatric illness with high cost to society and individual patients. Ages 62 and over. Location in Los Angeles, CA.
Telephone Based Cognitive Behavioral Therapy for HIV Related Depression. Interventional study. The purpose of this study is to evaluate the effectiveness of a telephone-based, cognitive behavioral therapy intervention in the treatment of depression in adults diagnosed with HIV. Ages 18 and over. Location in Baltimore, MD.
Shared Decision-Making for Elderly Depressed Primary Care Patients. Interventional study. Shared decision-making (SDM), in contrast to traditional medical decision-making, involves a collaborative process where patients discuss personal values and preferences and clinicians provide information to arrive at an agreed upon treatment decision. Ages 65-95. Locations in Bronx, NY; White Plains, NY.
fMRI Study of Treatment Changes in Major Depression. Interventional study. The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional anti-depressants do, to find out more about the causes of depression and why people differ in the extent of problems caused by depression, and to determine if certain differences in genes within populations are related to clinical symptoms. Ages 18-50. Location in St. Louis, MO.
Treatment for Depressed Primary Care Patients. Interventional study. This research study develop a collaborative depression care management model (C-DCM) that encourages collaboration between primary care physicians (PCPs) and trained social workers employed by community-based, public and nonprofit mental health clinics. Ages 60 and over. Location in White Plains, NY.
Depression Outcomes Study of Exercise. Interventional study. This pilot study may yield important research findings on how to adapt exercise treatment for depression among adolescents. Ages 12-17. Location in Golden, CO.
Concurrent Treatment for Depressed Parents and DepressedAdolescents. Interventional study. This study will develop an integrated treatment for adolescents who are depressed and suicidal and their parents who are depressed and have a history of suicidality. Ages 12-17. Location in Providence, RI.
Assessing Anterior Cingulate Brain Activity in People With Late-Life Depression. Evaluation study. This study will examine differences in activity of the anterior cingulate cortex, a brain area involved in emotion and cognitive regulation, between older adults with and without depression. Ages 60-85. Location in White Plains, NY.
Effectiveness of a Technology Assisted Behavioral Intervention in Assisting People With Major Depressive Disorder. Interventional study. This study will develop and evaluate the effectiveness of a technology-assisted behavioral intervention, consisting of Internet-based cognitive behavioral therapy combined with telephone and email support, in reducing depressive symptoms and improving treatment adherence in primary care patients with major depressive disorder. Ages 19 and over. Location in Chicago, IL.
Sequential Treatment of Pediatric MDD to Increase Remission and Prevent Relapse. Interventional study. This study will compare the effectiveness of fluoxetine alone with the effectiveness of fluoxetine with cognitive behavioral therapy in increasing recovery and preventing relapse in youth with major depressive disorder. Ages 8-17. Location in Dallas, TX.
Depression Prevention for Pregnant Women on Public Assistance. Interventional study. This study will evaluate the effectiveness of an interpersonal therapy treatment called the Postpartum Prevention Program in preventing the development of postpartum depression in pregnant women who are financially disadvantaged. Ages 18-40. Locations in Providence, RI; Woonsocket, RI.
Effectiveness of Behavioral Treatments for Obesity and Major Depression in Women. Interventional study. This study will compare the effectiveness of two weight loss programs, one supplemented with health education and the other supplemented with behavioral counseling, in treating women who are depressed and overweight. Ages 21-65. Location in Worcester, MA.
CBT for Adherence and Depression in Diabetes. Interventional study. This study will evaluate the effectiveness of cognitive behavioral therapy (CBT) in treating people with depression and type 2 diabetes. Ages 18-80. Location in Boston, MA.
Evaluating the Effects of Stress in Pregnancy. Evaluation study. This study will evaluate pregnant women with a past or current diagnosis of depression or anxiety to gain a better understanding of how these disorders can affect an infant's development, both during and after pregnancy. Ages 18-45. Location in Atlanta, GA.
Pharmacogenomics of Antidepressant Response in Children and Adolescents. Evaluation study. This study will identify variations in genes that may be involved in the development of suicidal events or certain behaviors in youth who are exposed to antidepressant medications. Ages 7-17. Location in Durham, NC.
Omega-3 Fatty Acids for Treating Adults With Major Depression. Interventional study. This study will test the effectiveness of two different kinds of omega-3 fatty acid dietary supplements in treating the symptoms of major depression. Ages 18-80. Location in Los Angeles, CA.
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients. Interventional study. The primary purpose of this protocol is to compare PDE4 levels before and after starting a selective serotonin reuptake inhibitor (SSRI) sertraline, citalopram or escitalopram in unmedicated depressed patients. Ages 18-55. Location in Bethesda, MD.
Identifying Factors That Predict Antidepressant Treatment Response. Interventional study. This study will compare different treatments for depression in order to identify which factors predict effectiveness, and will include a companion study which investigates combining treatments and long term effectiveness. Ages 18-65. Location in Atlanta, GA.
Interpersonal Psychotherapy for Depression in People With Heart Failure. Interventional study. This study will evaluate the effectiveness of interpersonal psychotherapy and behavioral activation techniques in treating depression in people with congestive heart failure. Ages 55 and over. Location in Iowa City, IA.
Group Intervention for Interpersonal Trauma. Interventional study. This study will assess the acceptability and effectiveness of a six-session, modular, repeating group for low-income women who have symptoms of depression and/or post-traumatic stress disorder following interpersonal trauma exposure. Ages 18-70. Location in Washington, DC.
Prevention of Depression in Spouses of People With Cognitive Impairment. Interventional study. This study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or family caregivers of persons with mild cognitive impairment or early dementia. Ages 18 and over. Location in Pittsburgh, PA.
Identification and Therapy of Postpartum Depression. Interventional study. This study will evaluate the effectiveness of a telephone-based depression screening and care management program in treating depression in postpartum women. Ages 18 and over. Location in Pittsburgh, PA.
Bipolar II Depression: Lithium, SSRI, or the Combination. Interventional study. This study will compare the safety and effectiveness of a mood stabilizing medication, an antidepressant medication, and a combination of both medications to treat symptoms of bipolar type II depression. Ages 18-65. Locations in Los Angeles, CA; Palo Alto, CA; Mason, OH.
Family Cognitive Behavioral Therapy for Preventing Depression in Children. Interventional study. This study will determine the effectiveness of cognitive behavioral therapy (CBT) versus educational treatment in preventing depression in the children of parents with a history of depression. Ages 10 and over. Location in Nashville, TN.
Effect of Family-Based Prevention on Children of Depressed Parents. Interventional study. This study will test the Protecting Families Program, a 10-week prevention program for depressed parents and their pre-teenage children, by comparing the effectiveness of the program versus parent training alone. Ages 9 and over. Location in Philadelphia, PA.
A Clinic-Based Prevention Program for Families of Depressed Mothers. Interventional study. This study will assess the effectiveness of the "Keeping Families Strong" program (KFS) in avoiding or delaying the onset of psychiatric disorders among children with depressed mothers. Ages 8 and over. Location in Baltimore, MD.
Hormonal Causes of Menstrual-Related Mood Disorders. Evaluation study. This study will explore possible hormonal causes of menstrual-related mood disorders (MRMD) by stopping the menstrual cycle with a drug called Lupron and then giving in sequence two menstrual cycle hormones, progesterone and estrogen. Ages 18-50. Location in Bethesda, MD.
Rapid Antidepressant Effects of Ketamine in Major Depression. Interventional study. This study examines whether Ketamine can cause a rapid-next day antidepressant effect in patients with Major Depression/Bipolar Disorder . Ages 18-65. Location in Bethesda, MD.
Function of Catecholamines in the Brain During Depression. Evaluation study. This study will explore brain function related to depressive symptoms and will examine DNA for genes that may be involved in depressive disorders, particularly genes that regulate synthesis and metabolism of the brain neurotransmitter catecholamine. Ages 18-45. Location in Bethesda, MD.
Rapid Antidepressant Effects of Yohimbine in Major Depression. Interventional study. This study examines if Yohimbine, when given during the sleep cycle, will improve symptoms of depression within a matter of hours. Ages 18-65. Location in Bethesda, MD.
Clinical Trial of Estrogen for Postpartum Depression. Interventional study. This study evaluates the efficacy of estrogen treatment in women with postpartum depression (PPD). Ages 20-45. Location in Bethesda, MD.
Screening Evaluation for Women With Postpartum Depression. Evaluation study. This study evaluates the relationship between mood changes and hormones in women with postpartum depression (PPD). Ages 20-45. Location in Bethesda, MD.
Raloxifene and Rimostil for Perimenopause-Related Depression. Interventional study. The purpose of this study is to evaluate the effectiveness of the drugs raloxifene and rimostil in treating perimenopause-related depression. Ages 40-60. Location in Bethesda, MD.
Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes. Evaluation study. This study uses functional magnetic resonance imaging (fMRI) to learn how the brain functions in adolescents receiving fluoxetine (Prozac) cognitive behavioral therapy (CBT) or interpersonal therapy (IPT) for anxiety or depression in children/adolescents. Ages 8-40. Location in Bethesda, MD.
Combined Hormone Replacement in Menstrually-Related Mood Disorders. Evaluation study. This study investigates the effects on symptoms of combined treatment with estrogen and progesterone in women with severe premenstrual syndrome (PMDD). Ages 18-50. Location in Bethesda, MD.
Perimenopause-Related Mood and Behavioral Disorders. Evaluation study. The purpose of this study is to investigate mood and behavior changes in the time period surrounding and including menopause. Ages 40-60. Location in Bethesda, MD.
A Treatment Study for Premenstrual Syndrome (PMS). Evaluation study. This study examines the effects of estrogen and progesterone on mood, the stress response, and brain function and behavior in women with premenstrual syndrome. Ages 18-45. Location in Bethesda, MD.
Brain Tissue Collection for Neuropathological Studies. Evaluation study. The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Locations in Washington, DC; Bethesda, MD; Fairfax, VA.
Evaluation of the Genetics of Bipolar Disorder. Evaluation study. This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions. Ages 18 and over. Location in Bethesda, MD.
The Role of Hormones in Postpartum Mood Disorders. Evaluation study. Determine whether postpartum depression is triggered by the abrupt withdrawal of estrogen and progesterone. Ages 18-40. Location in Bethesda, MD.
